It will be the fifth edition in a row that the two heavyweights have met head to head at a European Championship.
Italy were clinical in their approach as they beat Belgium 2-0 in their Euro 2016 Group E encounter on Monday.
Italy forward Graziano Pelle has been kicked out of the national squad over his angry reaction to being substituted against Spain when he refused a handshake from coach Giampiero Ventura.
Holders Spain were knocked out of Euro 2016 in a 2-0 defeat by Italy on Monday after goals by Giorgio Chiellini and Graziano Pelle set up a quarter-final with world champions Germany. Chiellini opened the scoring after 33 minutes while Pelle wrapped up the victory in stoppage time to end Spain's reign as European champions which covered the 2008 and 2012 tournaments.
Forget Italy's image of Catenaccio (or "door chain defence"). Antonio Conte's Italy showed in a 2-0 defeat of Spain at Euro 2016 on Monday that they can do unchained attacking football too. The Azzurri, who will take on world champions Germany in a fascinating quarter-final on Saturday, had promised they would not be afraid to go forward against Spain.
A round-up of Saturday's action in LaLiga, Serie A and Ligue 1.
Italy's Daniele De Rossi scored a late penalty to earn a 1-1 draw against Spain in their World Cup qualifier on Thursday, sparing home goalkeeper Gianluigi Buffon's blushes after he gifted the visitors the lead. Buffon, making his 164th appearance, rushed out of his area as Vitolo broke clear but the 38-year-old completely mistimed his tackle, allowing the Spaniard to go round him and put the ball into an empty net in the 55th minute. Italy, who had been outplayed in the Group G clash, fought back and levelled in the 82nd when Eder was fouled by Sergio Ramos and De Rossi converted the spot kick, their only shot on target in the match.
A superbly-executed strategy by coach Antonio Conte helped Italy to a deserved 2-0 win over Belgium in their Euro 2016 opener with outstanding goals by Emanuele Giaccherini and Graziano Pelle on Monday.
German players have no interest in thinking about past losing battles against Italy as they prepare to face them in the Euro 2016 quarter-finals on Saturday, with midfielder Toni Kroos sounding confident they will finally emerge victorious. The Germans have lost all knockout tournament matches against Italy stretching back to 1970 but playmaker Kroos was in no mood to discuss them.
Italy's victory over Belgium was celebrated as a triumph of the team over individual talents, but Friday's opponents Sweden are relying on the singular genius of frontman Zlatan Ibrahimovic to get their Euro 2016 campaign off the ground.
Like an ailing heavyweight, Spain and their hopes of a third straight European title ended in a tame surrender as their 2-0 defeat by Italy represented the definitive end to a golden era in their footballing history. A first-half effort from defender Giorgio Chiellini and a stoppage-time goal by striker Graziano Pelle sent the Azzurri into the quarter-finals at Euro 2016 and left Spain to mull over a second successive failure on the international stage.
Italy manager Antonio Conte named his provisional squad for the European Championship on Monday, and his selection was notable as much for the player he left off as for those he chose.
Midfielder Riccardo Montolivo missed out on his second straight major tournament due to injury on Tuesday while Daniele De Rossi was included in Italy's 23-man squad for next month's European Championship in France.
Germany's players hailed their first victory against Italy in a major tournament as an exceptional moment in their history as they reached the Euro 2016 semi-finals by beating their old rivals 6-5 on penalties.
Belgium make Wales wait after Hazard's strike, while Czechs beat Latvia to qualify
One hundred thirty-six people were charged with rioting and murder in connection with the killing of the India head of the Italy based company, a senior police official said on Tuesday. Meanwhile, companies in the Greater Noida industrial area have increased the number of security guards following yesterday's incident.
An inspired performance from Douglas Costa helped Brazil to a 3-0 win over Peru on Tuesday and lifted them into third place in the South American qualifying group for the 2018 World Cup in Russia.
Manchester United striker Wayne Rooney would be a "great signing" for Major League Soccer, Portland Timbers owner Merritt Paulson said, adding that the 30-year-old still has plenty to offer.
Italian great Valentino Rossi has not ruled out a return to MotoGP in Spain this weekend, three weeks after breaking his right leg, after getting back on a bike for some test laps on Monday.
Spain fullback Mario Gaspar scored with a stunning volley and midfielder Santi Cazorla added a late goal as the European champions handed England a chastening 2-0 defeat in a friendly between the continental heavyweights on Friday.
Malta make Italy sweat, while Bale takes Wales closer to competition
Wales continued their unbeaten start to the Euro 2016 campaign as a nervy 2-1 triumph over Cyprus, after they had been reduced to 10 men, bolstered the nation's dream of qualifying for a major championship finals for only the second time.
Spain started their World Cup qualifying campaign with a crushing 8-0 win over Liechtenstein, laying down a marker in Group G with a ruthless second-half display on Monday.
An inexperienced Germany suffered an embarrassing 3-1 defeat to Slovakia in a storm-affected friendly ahead of Euro 2016.
The Netherlands failed to reach the European Championship for the first time since 1984 as they lost 3-2 at home to the 10-man Czech Republic in their final qualifier on Tuesday to miss out on Euro 2016.
American swimmer Michael Phelps, the most decorated Olympian of all time, was suspended for six months by USA Swimming on Monday following his recent arrest on a drunken driving charge.
